Building and analysing an integrative model of HIV-1 RNA alternative splicing

Poster number: 27

A. Bockmayr (1,2), A. Courtois (2), D. Eveillard (2,3), M. Vezain (3)

  1. DFG Research Center Matheon & FU Berlin, Arminallee 3, 14195 Berlin, Germany
  2. LORIA, UMR 7503 (CNRS, INRIA, Universités de Nancy), BP 239, 54506 Vandoeuvre-lès-Nancy, France
  3. Laboratoire de Maturation des ARN et Enzymologie Moléculaire, UMR 7567, CNRS-UHP, BP 239, 54506 Vandoeuvre-lès-Nancy, France

We present a multi-site model describing the alternative use of the RNA splicing sites A3, A4, A5 and A7 in the human immunodeficiency virus HIV-1. Our goal is to integrate experimental data obtained on individual splicing sites into a global model of HIV-1 RNA alternative splicing. We give a qualitative validation of our model, and analyse the possible impact of variations of regulatory protein concentrations on virus multiplication.